The reason I feel uncomfortable watching The Big Bang Theory is because it’s laughing at me, at people like me.
Once again nerd culture is getting distorted by those who make TV. This time we (as geeks/nerds/$identifier) are actually expected to like people laughing at us?
In my own case, whenever I am laughed at I try to take stock of the situation. If I feel the response to that situation is unwarranted, I’ll drop off contact with the people involved, or try to avoid that place/environment as much as possible. If I cannot avoid them, I’ll just keep quiet and serious. That way there is no room for humor that could be directed at me.
Things like this make the planet a less strange word. A dimmer world. An unhappier world.